Renal adaptive response to exposure to low doses of uranyl nitrate and sodium fluoride in mice

Despite their differences in physicochemical properties, both uranium (U) and fluoride (F) are nephrotoxicants at high doses but adverse effects low still the subject of debate. METHODS: This study aims to improve knowledge biological mechanisms involved through an adaptive response model C57BL/6 J mice chronically exposed priming U (0, 10, 20 40 mg/L) or F 15, 30 50 then challenged with acute exposure 5 mg/kg 7.5 NaF. We showed that occurred exposures mg/L F, decreased levels biomarkers KIM-1 CLU compared those animals received challenge dose only (positive control). The a decrease caspase 3/7 activities situ VCAM expression F. However, autophagy UPR were induced independently could not be identified as Taken together, these results allow us identify renal responses mg/L, probably apoptosis inflammatory cell recruitment.